Uruli was mentioned in the Copperplate inscription of Shilahara King Aparajita in 993 AD. The village of Uruli Kanchan is quite known for its association with Mahatma Gandhi and his disciple Manibhai Desai. 
Mahatma Gandhi came to Uruli Kanchan on 22nd March 1946 and stayed at the village for seven days with his disciple Manibhai Desai. Together they started the Nature Cure Ashram. Gandhiji established Nisargopchar Gramsudhar Trust on 1st April 1946. He got donations in the form of Land by local donors such as Late Shri Mahadev Tatyaba Kanchan. The whole team under the Management of Manibhai Desai understood and studied the problem in the village and made safe and sound solutions for it. This ashram ran under the guidelines as stated by Gandhiji which included regulation of diet, fast, sun-bath, fomentations, steam-bath, mud- bandage, massage and non-injurious indigenous herbs. As of today after many glorious years of this Ashram, it continues to serve patients suffering from various chronic diseases which here are treated using a drugless holistic approach. Treatment is offered to patients suffering from Arthritis, cardiovascular diseases, diabetes, obesity, bronchitis, skin diseases, asthma. Digestive, gynaecological problems, and neuromuscular disorders.
Manibhai Desai also pioneered the  Bharatiya Agro-Industries Foundation (BAIF). It is quite a known fact the BAIF has been a pioneer in introducing the Indo-European hybrid cattle breed in India and it has proved a milestone in Indian Milk Industry. The whole area of Uruli Kanchan with the help of these great personalities has been transformed into some more just a village and these have paved the way for the village to become an urban centre one day.

The region has a hot-semi arid climate year-round with an average temperature ranging from 19-33 degrees Celsius.
April and May are the hottest months when the temperature reaches up to 42 degrees Celsius.
Winters are extreme, and the temperature can go as low as 10 degrees Celsius at night, but the average daytime temperature is around 26 degrees Celsius.
The annual rainfall in the region is around 763 mm.